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19 This discrepancy highlights the gap between efficacy observed in controlled trial settings and effectiveness in routine clinical practice

Elastin fibers are damaged and have limited capacity to regenerate naturally (adult humans produce very little new elastin after puberty under normal conditions)

Though squalane is often called an oil, its technically not one

1 Study design SELECT 1,4 : A multi-national, double-blind, placebo-controlled, event-driven CV outcomes trial of 17,604 adults with a BMI 27 kg/m and established CVD (prior MI, prior stroke, or PAD) assessing superiority of once-weekly Wegovy 2.4 mg vs placebo (1:1 randomization, with a 16-week dose escalation) for time to rst MACE

The most important point is that results depend on the clinical context