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Mechanisms of Action: From Obesity to Addiction GLP-1 agonists enhance insulin secretion, slow gastric emptying, and promote satiety by acting on GLP-1 receptors in the hypothalamus and other brain regions involved in hunger regulation

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STEP-8 compared semaglutide 2.4 mg once weekly head-to-head against liraglutide 3 mg once daily in 338 adults with obesity