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Whether they can be combined: some patients use both, under physician supervision, based on what an evaluation shows

In the United States, the list price of one popular medication is around $1,000 for a one-month supply , whereas the exact same medicine costs a tiny fraction of that in other countries (~ $100 in places like Canada and France)

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To keep in accordance with other parameters zonation levels, the non-linear patterns were defined to ensure 0%, 20%, 50%, and 80% variation from baseline, all in conservation of an average parameter equal to the original model value (as seen in Supplementary Figure S1)