In septic mice, semaglutide attenuated sickness behavior, hypothermia, systemic inflammation, and lung injury through the downregulation of pro-inflammatory cytokines (TNF- , IL-1, IL-6, CXCL1), suppression of neutrophil infiltration, and decreased expression of genes associated with tissue remodeling and inflammation (Mmp9, Timp1, Ly6g)
As the authors noted, the study is not set up to address causality
But when they build up faster than your body can neutralise them, it causes oxidative stress - basically, internal rusting
Lopaschuk GD: Current Concepts in Carnitine Research
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