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In contrast, those in the dose-escalation groups experienced lower discontinuation rates from gastrointestinal adverse events, with rates up to 7.8%

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The main mechanisms by which GLP1RAs promote tumor apoptosis encompass the cAMPPKAdependent pathway, the BMP4/Smad signaling pathway, the PI3K/Akt/mTOR signaling pathway, and the NF-B signaling pathway

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In addition, glucagon has re-emerged as a significant contributor to glucose homeostasis and energy metabolism [7]