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Interventions affecting systemic metabolism, such as NNMT inhibition, are likely to influence the gut microbiome

Direct Link Manavathu, M., S.Gunasekaran, O

Effects of Glucagon Like Peptide-1 Receptor Agonists on Tumor Diseases To date, a large number of epidemiological investigations have confirmed that the occurrence of endometrial cancer, hepatobiliary cancer, pancreatic cancer, breast cancer, prostate cancer, and colorectal cancer is positively correlated with T2MD (202, 203)

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Until such evidence is available for retatrutide, therapies with established cardiovascular and renal benefitssuch as semaglutide, supported by SUSTAIN-6 [5] and FLOW [57] trials in people with T2D, and the SELECT trial [58] in people with obesity - should be prioritised in populations with existing cardio-renal disease