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Description

Histamine is synthesized by the enzymatic decarboxylation of the amino acid histidine by the enzyme L-histidine decarboxylase (HDC)

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A 2023 systematic review in the Journal of Bone and Joint Surgery found moderate-quality evidence for MSC injections improving pain and function scores in knee osteoarthritis at 12 months, but no evidence of cartilage regeneration on MRI

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The implementation of such a program would require the determination and validation of standard molecular and microbiological methods, as well as the extended cost-utility analyses in collaboration with other professionals, including dietitians, microbiologists, and industry [88, 89]

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