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Together, they can offer a powerful, two-pronged attack on high blood sugar for people with type 2 diabetes who need more intensive therapy

Managing Side Effects Based on Dosing Time Gastrointestinal side effects particularly nausea, vomiting, diarrhoea, and constipationare the most commonly reported adverse effects of GLP-1 medications, especially during the initial weeks of treatment or following dose escalation

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However, DPRA is not suitable for metallic compounds, because they may form bonds with the nucleophilic residues in histidine 20