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Apart from this hydrophobic region, it seems that GLP-1R prefers a carboxyl group at the end of the side chain while GIPR can accommodate, but does not favor, an alkaline group
However, this attempt failed and this approach did not prove successful until the introduction of the incretin hormone glucagon-like peptide-1 (GLP-1) as the basis for glucose-lowering therapeutics in type 2 diabetes
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With TGR being a probable important drug target for treatment of schistosomiasis, is it an essential protein for the parasite
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