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Introduction T cells are essential components of adaptive immunity, recognizing antigens presented by antigen-presenting cells and executing effector functions ranging from cytokine production to cytotoxic activity ( It is increasingly recognized that immune cell function is strongly shaped by the local microenvironment, including oxygen tension, nutrient availability, and metabolic constraints ( Beyond these clinical contexts, immune cells in peripheral tissues are chronically subjected to subphysiological temperatures
W., Fndriks, L
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