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Description

While some fatigue is common during early weight loss, progressive weakness, particularly if accompanied by muscle pain or cramping, may suggest inadequate protein intake, electrolyte imbalances, or other metabolic concerns that require evaluation

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Until that qualification work is done, the imaging and fluid measures are instruments for understanding the mechanism and selecting patients, while the question of whether these drugs modify the disease still belongs to the clinical endpoints

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However, treatment discontinuation due to adverse events occurred in 24.6% and 3.9% of participants, respectively, mainly due to gastrointestinal adverse events

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