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Management of fatigue in patients taking GLP-1 receptor agonists begins with thorough assessment to identify contributing factors and exclude serious underlying conditions

When you restart after a significant break, you will likely need to begin at the starting dose again to let your body re-acclimate safely

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The glucagon receptor component is hypothesised to enhance energy expenditure and fat breakdown, which researchers believe may contribute to greater weight loss compared with dual or single agonists though this remains under investigation and has not been definitively established