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A: The circadian rationale remains the same, but older adults (50+) show reduced amplitude of the endogenous nocturnal GH pulse, making the peptides' amplification effect even more critical

AD is characterized by a decade-long prodromal stage, and dementia diagnosis typically occurs in the late biological stage of AD, by which time substantial amounts of A and tau proteins have accumulated in the cortex [101]

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Notably, Aza-TdC reactivated the gluconeogenic enzyme-encoding gene phosphoenolpyruvate carboxykinase 1 ( PCK1 ), which was hypermethylated and transcriptionally repressed in MASLD

The absence of early weight loss does not indicate lack of effectiveness, as foundational appetite and metabolic changes are still underway