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The glucose-dependent nature of insulin secretion with GLP-1 therapy represents a significant safety advantage
Generic medications tend to be Sandoz is building its GLP-1 development platform, and this submission reflects true in-house innovation, said Claire DAbreu-Hayling, the president of Generics Development and the chief scientific officer at Sandoz, in a press statement
Similarly, liraglutide has been shown to enhance the efficacy of PD-1 inhibitors in the treatment of lung cancer and liver cancer [93]
Already, scientists have shown that GLP-1 drugs like semaglutide can lower the risk of heart attack and stroke, reduce signs of kidney and liver disease and treat sleep apnea, among other effects
1 Thus, numerous studies have used biotechnology to extend the half-life of GLP-1 RAs, with strategies including amino acid sequence substitution, fatty acid conjugation with a linker, fusion of albumin or the IgG fragment crystallizable (Fc) region (Figure 1)
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