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Although aggressive weight loss improves glycemic and cardiovascular outcomes, it may increase transient gallstone formation
de Ligny et al
Periodic blood work may be required for spironolactone use
Dosing fundamentals Administration: Once weekly subcutaneous injection Same day each week (consistency matters) Preferably at the same time of day Half-life: Approximately 6 days, supporting weekly dosing Dose escalation: Every 4 weeks, unless: Side effects require holding current dose Individual tolerance suggests faster/slower progression Healthcare provider recommends adjustment Clinical trial doses tested The Phase 2 obesity trial tested multiple dosing arms: Key insight: 8 mg produces nearly the same results as 12 mg with fewer side effectsmaking it a potential "sweet spot" for many users
Patients on tesamorelin frequently report improvements in sleep depth and recovery, likely due to the normalized pulsatile GH pattern
