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Because it works by changing the way your body produces new pigment, the process is gradual
Evidence boundary The largest Phase 2b trial used oral dosing for 24 weeks and did not show statistically significant weight loss versus placebo
Risk Manag Healthc Policy 2: 1-7
More specifically for GLP-1 therapy, a 2025 systematic review of preclinical and human studies found encouraging signals of structural, immunomodulatory, and analgesic benefit, but also noted that human evidence remains limited, with only a small number of clinical studies and very sparse structural data (Cheng et al., 2025)
If you're taking any other medications or have an existing health condition, it's important to speak to your GP before trying them
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