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Marie, J

Based on our data, we propose that T3 has a regulatory role in insulin-controlled glucose metabolism, and T3 exerts this function by increasing non-12-OH FXR-antagonistic BA levels via downregulating the expression of CYP8B1, which potentiates GLP-1 production via suppressing the intestinal FXR signaling

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The SURMOUNT trials all used injectable formulations, and the weight loss results we referenced earlier came specifically from subcutaneous injections