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This should include thyroid function testing (TSH, free T4), A1C or fasting plasma glucose (per ADA guidelines), and targeted additional testing based on clinical suspicion

Warning signs include losing more than 2 pounds per week consistently (per CDC guidance on safe weight loss rates), severe weakness or dizziness, inability to maintain adequate protein or caloric intake, signs of muscle wasting, or cold sensitivity so severe that it significantly impacts quality of life or daily functioning

The standard schedule raises the dose every four weeks, from 2.5 mg through 5, 7.5, 10 and 12.5 mg up to the maintenance dose of 15 mg

Meanwhile, female Glp1r fl/fl mice treated with mGIPR-Ab/P1 lost 19.4% of their body weight

Patients frequently report that foods they previously enjoyed no longer hold the same appeal, and satiety signals become more reliable and pronounced