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In human studies, oral ingestion of collagen peptide preparations has been shown to induce transient postprandial increases in specific peptides such as ProHyp and GlyProHyp in plasma, supporting their systemic availability and potential to reach dermal targets [46]
Therefore, we can conclude that the inhibition of mitochondrial activity by metformin is probably the driver of the phenotype observed here
A., Kim, K
Additionally, serum chemistries and clotting studies can help evaluate organ function and the bloods ability to clot properly
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