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Infiltrating CCR2 monocytes become pro-inflammatory macrophages, releasing NO, ROS, IL-1, and TNF-, which enhances microglial priming and causes mitochondrial stress in dopaminergic neurons
It also regulates pineal gland function, supporting circadian rhythms and hormonal health
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The broader TRIUMPH clinical trial program has enrolled more than 5,800 participants across studies examining retatrutide for obesity, overweight, obstructive sleep apnea, knee osteoarthritis, chronic low back pain, cardiovascular and renal outcomes, and metabolic dysfunction-associated steatotic liver disease
