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[11] Use is not recommended in those who are allergic to cobalt or have Leber's disease

Serious side effects include muscle weakness, extreme thirst, confusion, shortness of breath, headache, exhaustion, reddening of the skin, and a fast or irregular heartbeat

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In clinical research settings, this difference matters most in how each compound is measured: Tesamorelin has been studied in trials involving GH and IGF-1 level changes, while AOD-9604 research has focused specifically on lipolysis and fat oxidation markers without the same IGF-1 elevation a distinction documented in peer-reviewed pharmacology literature comparing hGH fragments to full GHRH analogs

Metabolic Safety: IGF-1 and Glucose Effects One of the most clinically significant safety findings relates to AOD-9604s metabolic profile, particularly its lack of effects on insulin-like growth factor-1 (IGF-1) and glucose metabolism