Clinical trials show GLP-1 receptor agonists reduce waist circumference by approximately 13.5 cm with semaglutide after 68 weeks, with imaging studies demonstrating significant decreases in visceral adipose tissue volume
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"Our trial findings showed that among obese patients with HFpEF, once-weekly subcutaneous semaglutide was superior to placebo in improving patient-oriented quality of life outcomes and body weight at 52 weeks," the researchers wrote
Weeks 16-12: Retatrutide at 2-4mg