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It should be noted that the musculoskeletal evidence base remains preclinical, a 2025 scoping review by McGuire and colleagues in Current Reviews in Musculoskeletal Medicine found no adequately powered randomised controlled trials

Some signs that require medical attention include: Frequent heartburn (more than twice a week) Regurgitation (food or stomach acid coming back up into the throat) Persistent nausea or vomiting Chest pain that does not improve with antacids Difficulty swallowing or feeling like food is stuck in the throat Unexplained weight loss that is not due to the intended effects of semaglutide Doctors can assess symptoms and determine if they are caused by semaglutide, GERD, or another condition

The trend continued this year, with six of the 19 warning letters including language of this kind

Retatrutide may cause mild side effects such as nausea, vomiting, diarrhea, constipation, or stomach discomfort, which often improve as your body adjusts

For example, dosages of 1,000 mcg or more are routinely used to treat deficiencies without major concern for toxicity