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Disorders of metabotropic glutamate (mGlu) receptors and neurotrophins have significant negative effects on neuroplasticity, leading to depression, but LAC regulate brain type 2 metabotropic glutamate (mGlu2) receptors and N-methyl-D-aspartic acid (NMDA) receptors to induce antidepressant effect (8385)
The body temperature was maintained at 37C0.5C with a servo-controlled heating pad
This fasting period is meant to minimise the risk of aspiration of gastric contents, a potentially serious complication where gastric contents can enter the lungs during the procedure
They found that genetically reducing mast cells in mice completely prevented osteoarthritis
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