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Hypothalamic substrates of reward

New or worsening symptoms such as visual changes, severe headache, or signs of thyroid nodules (neck mass, difficulty swallowing) warrant evaluation

Weight loss begins in earnest, typically 2-4% of body weight by week 8

Therapy with GLP-1RA should therefore start with low doses that can be uptitrated ( GLP-1RA has been placed prominently in the international recommendations for the treatment of T2D as the first injectable agent before insulin due to the advantageous outcomes in cardiovascular safety studies that demonstrated a reduction of the combined cardiovascular endpoint three-component major adverse cardiovascular event (MACE-3