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In a phase 2 trial, once-weekly cagrilintide produced dose-dependent weight reductions in people with overweight or obesity, which is what moved the amylin pathway into serious combination development ( Lau et al., Lancet 2021 )
The C677T variant is linked to decreased arsenic detoxification and increased skin lesions with exposure.[ref][ref] Related article: Arsenic detoxification genes Additionally, methylation is important in detoxifying mercury
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Levels increase with age and higher levels are more common in men than women
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