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First, they reviewed evidence about the neuroprotective mechanisms of GLP-1RAs, mainly from pre-clinical studies, but with an emphasis on the few human studies available, looking at brain energy homeostasis, neurogenesis, synaptic functioning, neuroinflammation and other cellular stress responses, pathological protein aggregates, proteostasis, cerebrovascular system and blood-brain barrier dynamics

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Arch Clin Biomed Res

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