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[ref] A 2025 study showed that patients with RLS had higher serum IL-13 (inflammatory cytokine) levels and altered natural killer cell levels.[ref] The IL-13 connection is interesting, since IL-13 is elevated in asthma and allergies, tying back to altered histamine levels in the brain

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doi: 10.1016/j.bbamcr.2012.06.019 45 ClausenT