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The tripeptide has a donor-atom arrangement that binds copper(II) with high affinity under physiological conditions, and once that was appreciated it became clear that most of the reported activity tracked the complex rather than the free ligand

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Together, they: Enhance mitochondrial efficiency , ensuring that the body uses fat stores for energy

GLP-1 receptor agonists were originally developed to treat diabetes, but they are being used more and more to help obese and overweight patients lose weight