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Liraglutide was found to activate osteoblast proliferation by promoting the Wnt signaling pathway and p-AMPK/PGC1 signaling pathway, and inhibit osteoclast activation by suppressing the OPG/RANKL/RANK signaling pathway through anti-inflammatory, antioxidant, and anti autophagic pathways, thereby reversing bone loss (20)
Direct supplementation risks disrupting the body's innate GH rhythm, potentially resulting in side effects like joint pain, muscle aches, or even more severe conditions like diabetes
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Most patients on GLP-1 medications should aim for 1.01.5 grams of protein per kilogram of ideal body weight daily, which translates to approximately 0.450.68 grams per pound of goal weight
