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Mcl-1/CDK9Targeting by AZD5991/AZD4573 Overcomes Intrinsic and Acquired Venetoclax Resistance in vitro and in vivo in PDX Model of AML through Modulation of Cell Death and Metabolic Functions

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Nitric oxide modulation appears to affect blood flow and vascular tone, while VEGF-related pathways support new vessel formation and tissue recovery