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Neither option is universally "better." Many laboratories routinely use BAC water because its preservative supports repeated handling, while certain experimental protocols specifically require preservative-free sterile water

10.1016/j.jddst.2015.12.008 152 LiH

Shoeibi, A., Olfati, N., Soltani Sabi M., et al

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In a 56-day phase-2 trial, 9 participants with severe dry eye syndrome were treated with synthetic TB4 eye drops or placebo for 28 days, followed by a 28-day observational period