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Steric hindrance from the increased side-chain volume of E14 Cagri and R17 Cagri promotes a shift of the -helix of Cagri away from ECL2 and a slight expansion of the peptide binding pocket at the extracellular side of the CTR TM domain, relative to those observed with rAmy/San385-bound AMYR complexes

Prioritize protein-rich foods like chicken, fish, eggs, and Greek yogurt, which digest more slowly and maintain satiety without triggering additional stomach discomfort

Brzezinski A, Vangel MG, Wurtman RJ, et al

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