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Semin Reprod Med (2012) 30(1):513
The overactivation of the hypothalamicpituitaryadrenal (HPA) axis induced by chronic pain can interfere with GnRH pulses and inhibit testosterone synthase activity, exacerbating metabolic disturbances in the spermatogenic microenvironment
Unlike core peptides, KPV's effects are not mediated through MC-Rs, suggesting alternative pathways such as IL-1 inhibition
Pucci C, Martinelli C, Ciofani G
These data indicated that the electron-withdrawing substituents very possibly provided enhanced potency
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