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The neuroprotective benefit may stem from GLP-1s role in insulin signaling within the brain, where insulin resistance is a recognized early feature of Alzheimers pathophysiology
The exception to that is found, however, in many disease states (including hyper- and hypo-thyroid states), as well as in conditions relating to specific types of diets (high-fat, high-protein, and low-carb)
But the protein-first structure and mindset should stay in place
A pivotal study published in the New England Journal of Medicine reported that participants who received the highest dose of Zepbound (15 mg) lost an average of 22.5% of their body weight after 72 weeks of treatment
Some people whove experienced dramatic weight loss with GLP-1s like Ozempic and Wegovy say the effects are more noticeable on the tops of their feet, where tendons and veins are more prominent
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