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The successful loading of DOX through stacking interactions was confirmed by the redshift and broadening of the characteristic UV-vis absorbance peak of LAAM GSH-CQDs from 604, 627, and 676 to 609, 635, and 687 nm, respectively, forming the DOX/LAAM GSH-CQD complex (Supplementary Fig

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A negative balance occurs when protein degradation is greater than protein synthesis

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[16] [17] In obesity trials (SURMOUNT program), higher doses produced weight loss averaging 15-20% of body weight, while diabetes trials (SURPASS program) showed more modest but still significant weight reductions