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Vitamin B12 supplementation is available in several forms, including oral tablets, sublingual (dissolved under the tongue) preparations, nasal sprays, and intramuscular injections (commonly known as B12 shots)

Although inflammation of the terminal ileum is common in Crohn disease and ulcerative colitis, some studies report that vitamin B12 deficiency is uncommon in these populations (30), whereas others report rates of vitamin B12 deficiency as high as 14% among patients with Crohn disease (30

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Preclinical studies indicate that NNMT knockdown or inhibition can protect against diet-induced weight gain and improve metabolic parameters without reducing food intake [8] [9]