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Symptoms include redness, itching, and irritation of the glans penis and foreskin, sometimes with a white discharge beneath the foreskin

Tangphao O, Chalon S, Coulston AM, Moreno H, Chan JR, Cooke JP, et al

How it works: It boosts insulin production and suppresses glucagon release to control blood sugar

It also states plainly that no large randomized trial has compared the combination against either agent alone, so the pairing rests on mechanistic reasoning rather than outcome data

Acknowledgements We thank all the patients, investigators, and trial-site staff members who were involved in the conduct of the trial