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[1] [2] It is administered once weekly via subcutaneous injection and should be used alongside diet, physical activity and behavioural support

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In a 2-year trial involving patients with type 2 diabetes mellitus (T2DM) and high cardiovascular risk, more events of diabetic retinopathy complications occurred in patients treated with semaglutide 0.5 and 1 mg once weekly injections (3%) compared to placebo (1.8%)

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And critically, it acts on the hypothalamus to reduce appetite, creating powerful satiety signals that make people eat significantly less without feeling deprived