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9-12 These observations, coupled with mechanistic studies in HFpEF showing structural and functional cardiac differences in patients with LVEF 60% to 65%, have fueled a debate on the differential effects of interventions in patients with HFmrEF, and within the range of LVEF in those with true HFpEF
This wasn't a fluke finding buried in noise: the signal held across multiple GLP-1 agents, suggesting a class effect on reward pathways rather than random correlation
This wide range of applications underscores gabapentins utility in modern medicine, often serving as a critical component in improving the daily lives of individuals managing chronic conditions
Metformin treatment continued throughout the study at a stable dose
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