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A 2025 systematic review and meta-analysis in JAMA Psychiatry found no overall increase in psychiatric side effects, including depression, with GLP-1 medications

[4] The annual economic burden was about US$103 billion in the United States in 2016

Furthermore, it is well-established that many of these species can give rise to secondary oxidants with different reactivity and lifespan than the initial ones (reviewed in Halliwell and Gutteridge, 2015)

Huang, Y., Chen, Z., Chen, B., Li, J., Yuan, X., Li, J., Wang, W., Dai, T., Chen, H., Wang, Y., Wang, R., Wang, P., Guo, J., Dong, Q., Liu, C., Wei, Q., Cao, D., & Liu, L

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