The most harmful scenario is having gene variants that reduce glutathione levels and high toxin levels that deplete glutathione
However, long-term human safety trials are lacking, so usage should be approached with caution
Park C, Ji SY, Hwangbo H, Shin SY, Kim MY, Lee K, Kim DH, Cho BR, Lee H, Choi YH, You HJ (2023) Enhancement of Immune Functions by Limosilactobacillus reuteri KBL346: In Vitro and In Vivo Studies
Glutathione pairs well with Vitamin C, Vitamin E, and other antioxidants
Published work describes changes in collagen transcripts, in glycosaminoglycan and proteoglycan synthesis, and in the balance between matrix metalloproteinases and their tissue inhibitors, the TIMPs