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The importance of glucose-dependent insulinotropic polypeptide receptor activation for the effects of tirzepatide
The many faces of vitamin B12: catalysis by cobalamin-dependent enzymes
As also observed for FOXO4 FH binding, the R 1 relaxation rates of p53 194 remained unaltered in presence of FOXO4-DRI (Supplementary Fig
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Furthermore, MD revealed decreased flexibility of p53 TAD2 in complex with FOXO4-DRI compared to the FOXO4 FH -bound state with RMSDs of 1 heteronuclear NOE data was recorded using the HSQCNOEF3GPSI bruker pulse sequence (32 scans, 256 points in F1, 1024 points in F2, 1278.772 Hz spectral width in F1, 9615.385 Hz spectral width in F2) using a three seconds saturation period
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