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An early publication in the Annals of the New York Academy of Sciences documenting the original discovery of telomere shortening as a primary mechanism of cellular senescence and its relevance to human aging biology provides the foundational framework for understanding why telomerase-activating compounds attract longevity research attention

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B., Oreskovic, I., Ziger, T., Novinscak, T., Krezic, I., Strbe, S., Drinkovic, M., Brkic, F., Popic, J., Skrtic, A., Seiwerth, S., Staresinic, M., Sikiric, P.,

However, practical experience suggests both approaches produce beneficial outcomes, with the choice often driven by convenience rather than optimization concerns

It becomes more sensitive to temperature and light