An urgent priority is the development of robust, clinically validated biomarkers that can accurately reflect redox status, including both oxidative and reductive imbalances, in real time
Chemistry A European Journal, 31 (16), e202403755
This will provide evidence to support clinical trials targeting ferroptosis and ultimately enable a full pipeline from basic mechanisms to translational tools and clinical application, ensuring that ferroptosis-based therapies progress from laboratory research to patient care
WT-Bcr-Abl-transformed 32D cells were transplanted into C3H/HeNCrNarl mice
Additionally, the current study showed that in rats with GN-induced ARF, our treatment regimens, which include solo LS, GSH, and their combination in both NP formulations, significantly reduced serum cystatin C levels and renal tissue concentrations of NGAL and KIM-1, indicating a linked improvement in ARF