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J Neurointerv Surg

Lysosome-associated membrane protein-2 deficiency increases the risk of reactive oxygen species-induced ferroptosis in retinal pigment epithelial cells

(2016) 37:e140

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Factors of glutathione deficiency include: Exposure to chemical toxins (including environmental pollution) UV radiation exposure Chronic stress Excessive alcohol use Smoking Poor diet Certain medications And we see the deficiency manifest as wrinkles, inflammation, hyperpigmentation and melasma