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If you have any questions or concerns about what dose of B12 is best for you, talk with your doc for guidance
Any combination therapy should be implemented under medical supervision with appropriate monitoring
Once symptoms improve, a lower dose might be used
Nicotinamide is the precursor for NAD+ salvage the recycling pathway that regenerates NAD+ from the nicotinamide produced by sirtuin and other NAD+-consuming reactions
It is one of the reasons bedtime dosing is not just preferred but specifically designed into this protocol
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