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In a recent study, tamoxifen-xanthene hybrid induced mitochondria-mediated apoptosis due to activation of PARP cleavage, upregulation of Bim gene expression and increase in Bax/Bcl2 ratio in MCF-7 cells [99]
barometz hair displayed an up-regulation of HSP70 proteins that contributed to the protection of stomach cells from heat shock, oxidative stress, and down-regulation of the Bax proteins
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