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Not to get too deep into the science, but a PPAR agonist delivered selectively because of GLP1 and GIP receptors may mean that we can see the insulin sensitizing benefit of this drug class without the negative side effects that prior meds in this class have suffered from

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Diabetic retinopathy complications have been observed primarily with semaglutide, particularly with rapid glucose improvement in patients with pre-existing retinopathy, warranting ophthalmologic monitoring in high-risk individuals