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Published research (Stoeva MK et al., Gut Microbes, 2021) on Clostridium butyricum confirms it is a direct butyrate-producing organism in the gut

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Prakash, Krishna et al (2022) Trncated Human IRF-1 (1-233) protein shows neutral transcriptional effect on expression of Bax, survivin, Bcl2 and cyclin D1 genes in HEK293T cell line

Narrative reviews discuss that high pricing, insurance exclusions, and concerns about the appropriateness of prescribing may reinforce existing disparities and stigma [89]

Clinical trials have evaluated its use over periods of up to 72 weeks, and treatment is generally continued for as long as it remains effective and well tolerated